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Sesderma is a pioneering Spanish brand founded by dermatologist Dr. Gabriel Serrano — one of the first to use liposomal technology in cosmetics. A liposome is a microscopic lipid vesicle that transports active ingredients deeper into the epidermis, allowing the active to work at a lower concentration and causing less irritation. At J'ADORE Instytut, we have the widest portfolio of the brand in our store: nearly 180 products for face, body, hair, and hygiene.
How to read Sesderma product lines
The brand names its lines after the main ingredient, which makes choosing very easy once you know the key:
- C-VIT — Vitamin C: liposomal serum, 12% ampoules, brightening cream, eye contour, pads, mask, body milk, and CC cream.
- HIDRADERM and HIDRALOE — hydration with hyaluronic acid and aloe vera: creams, serums, body milks, shower gels.
- AZELAC and AZELAC RU — azelaic acid for redness, rosacea, and hyperpigmentation; RU is the enhanced version with SPF 50 emulsion.
- ACGLICOLIC — glycolic acid: cream-gel, forte ampoules, liposomal serum, SPF 15 cream.
- MANDELAC — mandelic acid, a gentler alternative to glycolic, also for sensitive skin.
- SALISES — salicylic acid for oily and acne-prone skin.
- RETIAGE, RETISES, RETISIL, SESRETINAL — retinol and retinal in various carriers and strengths.
- FACTOR G RENEW and SESGEN 32 — growth factors and cellular activation, anti-aging lines.
- REPASKIN — one of the most extensive SPF 50 lines on the market: fluids, sprays, tinted versions, mineral versions for children, Urban 365 anti-aging, and brightening products.
- SENSYSES — micellar waters in six variants tailored to skin condition.
- SESKAVEL — trichology: shampoos, ampoules, and masks for hair loss.
- BABYSES — baby and child care.
What are the benefits of the liposomal form?
Sesderma labels some products as "liposomal serum." The practical difference is that the substance enclosed in a liposome is released gradually and penetrates deeper, so the same actives — retinol, vitamin C, azelaic acid — are often better tolerated than in classic formulas. This is a great solution for those who have tried retinol and had to stop due to irritation.
Frequently Asked Questions
Where to start when first encountering the brand? The safest start is the HIDRADERM line (hydration) plus REPASKIN (sunscreen). Only then, build on this base by adding actives for specific problems.
Can C-VIT be used with acids? Yes, but at different times of the day — Vitamin C in the morning, acids in the evening.
Is REPASKIN suitable under makeup? Silk Touch and Dry Touch have a matte finish and work well as a base. Tinted versions can replace a light foundation.
See also: hydration, vascular skin, SPF creams.








































