AZELAC RU Cream-Gel 50 ml Sesderma
Azelac RU — gel
A fast depigmenting booster with growth factors.
This is a gel from the Azelac RU line by Sesderma — a Spanish brand that has built its formulations on liposomal technology for years: active ingredients are enclosed in microscopic phospholipid vesicles, allowing them to penetrate deeper and release gradually rather than acting aggressively from the very first minute.
Packaging capacity: 50 ml.
Three concerns, one active ingredient
Azelaic acid is a truly exceptional ingredient in dermatology because it simultaneously targets three issues that usually require three separate preparations: redness, blemishes, and hyperpigmentation. It does so gently, which is why the Azelac line is exceptionally well-tolerated by sensitive and couperose skin types that struggle with traditional exfoliating acids.
- —Reduction of erythema. It exhibits anti-inflammatory properties, soothing redness and the sensation of a "hot face".
- —Normalization of keratinization. It regulates the exfoliation process within the follicular openings, reducing the tendency for blackheads to form.
- —Brightening. It inhibits excessive melanin production in areas affected by inflammation.
- —Microbiome soothing. It limits the proliferation of bacteria that contribute to blemishes.
What's inside
Naturally found in grains. Highly prized in cosmetics for combining anti-inflammatory, normalizing, and brightening effects without drying out the skin.
Sesderma encapsulates azelaic acid in liposomes, ensuring gradual penetration and avoiding the stinging typical of high concentrations in traditional bases.
Complement the formula with a calming effect, making the treatment suitable even for reactive skin types.
How to apply — gel
1. Apply a thin layer to cleansed skin.
2. Spread gently, tapping in until fully absorbed.
3. Use morning and evening unless instructed otherwise on the packaging.
4. In the morning, finish your routine with an SPF 50 sunscreen.
Who is the Azelac line for
Azelac is designed for skin prone to redness that also struggles with blemishes or post-blemish marks. This is a very common combination that is notoriously difficult to manage with a single product.
- —Couperose and erythema-prone skin. Reacts with redness to temperature changes, stress, and skincare products.
- —Skin with blemishes. Blackheads, papules, oily skin in the T-zone.
- —Post-inflammatory hyperpigmentation. Dark marks that linger after breakouts for weeks or months.
- —Skin intolerant to acids. Prone to stinging and irritation following traditional exfoliation.
Q&A
Azelac is the base line featuring azelaic acid. Azelac RU is an enhanced version containing a depigmenting complex — it is the preferred choice when hyperpigmentation is the primary concern, rather than redness alone.
In its liposomal form, it rarely does. You may experience a mild warming sensation at the start of the treatment, which typically subsides after a few days. Start by applying it every other evening.
Yes. Unlike AHA acids, azelaic acid does not make the skin photosensitive. However, sunscreen remains mandatory if you are treating hyperpigmentation.
For redness and blemishes, results are often visible after one month. Hyperpigmentation requires patience — a minimum of three months.

„Sesderma is a Spanish dermocosmetic brand founded in 1989 by Dr. Gabriel Serrano — a pioneer of liposomal technology in at-home skincare.”
I'll gladly advise whether AZELAC RU Cream-Gel 50 ml will work for your needs — answer a few questions in the skincare finder and we'll immediately match the care to your skin and the order of use.
Recommended by our cosmetologist · loved by clients
Not sure which Sesderma product to choose for your skin? Write to us — we will help you choose skincare tailored to your needs.
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