SESPANTHENOL Cream-Gel 100 ml Sesderma
Sespanthenol — gel
This liposomal cream soothes itching and redness associated with skin irritation.
This is a gel from the Sespanthenol line by the Spanish brand Sesderma, which has based its formulas on liposomal technology for years: it encapsulates active ingredients in microscopic phospholipid vesicles, allowing them to penetrate deeper and release gradually rather than acting abruptly from the first minute.
The package capacity is 100 ml. Key active ingredients in this formula: panthenol. Indications: soothing/sensitivity, capillaries/erythema.
Panthenol — a first-aid ingredient
Panthenol, or provitamin B5, converts into pantothenic acid in the skin and supports epidermal repair processes. It is one of the most thoroughly researched and safest soothing ingredients, which is why it is used wherever skin is irritated, dry, or in need of healing support.
- —Regeneration support. Accelerates the reconstruction of damaged epidermis.
- —Hydration. Binds water in the stratum corneum and softens the skin.
- —Anti-inflammatory effect. Calms redness and burning sensations.
- —Barrier strengthening. Improves the integrity of the skin's protective layer.
What's inside
Converts into pantothenic acid in the skin, supporting epidermal regeneration and soothing irritation.
Retains water in the stratum corneum, softening rough skin.
Improves ingredient penetration and ensures their gradual release.
How to use — gel
1. Apply a thin layer to cleansed skin.
2. Spread gently, patting until absorbed.
3. Use morning and evening, unless the packaging indicates otherwise.
4. In the morning, finish your ritual with an SPF 50 sunscreen.
Who is the Sespanthenol line for
Sespanthenol is regenerative care for irritated skin — after treatments, sun exposure, hair removal, or in case of dryness.
- —Irritated skin. Red, burning, or after exposure to irritants.
- —Post-treatment skin. Requiring regeneration support.
- —Dry skin. Rough and tight, prone to cracking.
- —Hands and exposed areas. Frequently in contact with water and detergents.
Q&A
Yes, it is one of the best-tolerated skincare ingredients.
Yes, panthenol is a classic ingredient for post-treatment care. Please consult your specialist regarding the specific timing for application.
Panthenol is safe, but for infants and young children, please opt for products specifically formulated for them.
During periods of irritation, it can be used several times a day; otherwise, use as needed.

„Sesderma is a Spanish dermocosmetic brand founded in 1989 by Dr. Gabriel Serrano — a pioneer of liposomal technology in at-home skincare.”
I'll gladly advise whether SESPANTHENOL Cream-Gel 100 ml will work for your needs — answer a few questions in the skincare finder and we'll immediately match the care to your skin and the order of use.
Recommended by our cosmetologist · loved by clients
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